Evolution of regenerative endodontic in young permanent teeth: a literature review

Objective: to compare different protocols available for regenerative endodontic. Methodology: articles published between 2001 and 2021 were searched on the database PubMed using following keywords: “pulp revascularization” or revitalization” “apexification”. Inclusion criteria studies humans, patients with immature permanent teeth necrosis irreversible pulpitis, a follow-up of at least 12 months, clearly described in English language. Results: The search produced 944 results. After applying inclusion exclusion criteria, only 35 selected. 11 added bibliographic review selected total 46 cases included. success rate outcome endodontic was 80% observed 278 teeth. During irrigation, NaOCL used most concentration varying from 0.5% 6% TAP has been intracanal medication (32.7%). Periapical healing resolution symptoms 95.7%, while apexogenesis 80.2%. Increase root length reach 60%, thickness 64.8% apical closure 61,9%. Pulp vitality found 7.2% discoloration 29.5%. Conclusion: Regenerative showed signs cases, pronounced increase thickness, apex. Due high number their heterogenicity, superiority one over others cannot be established. More randomized clinical trials are needed determine effective protocol.